Thomas M File Selected Research

lefamulin

1/2022	A plain language summary of how lefamulin alone can be used to treat pneumonia caught outside of the hospital due to common bacterial causes, including drug-resistant bacteria.
1/2022	Pooled microbiological findings and efficacy outcomes by pathogen in adults with community-acquired bacterial pneumonia from the Lefamulin Evaluation Against Pneumonia (LEAP) 1 and LEAP 2 phase 3 trials of lefamulin versus moxifloxacin.
12/2021	Lefamulin in Patients with Community-Acquired Bacterial Pneumonia Caused by Atypical Respiratory Pathogens: Pooled Results from Two Phase 3 Trials.
5/2021	Lefamulin efficacy and safety in a pooled phase 3 clinical trial population with community-acquired bacterial pneumonia and common clinical comorbidities.
12/2020	Lefamulin: A Novel Semisynthetic Pleuromutilin Antibiotic for Community-acquired Bacterial Pneumonia.
1/2020	Erratum to: Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.
11/2019	Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Thomas M File Research Topics

Disease

48	Pneumonia (Pneumonitis) 01/2022 - 01/2002
25	Infections 01/2022 - 10/2002
13	Bacterial Pneumonia 01/2022 - 05/2012
9	Healthcare-Associated Pneumonia 08/2017 - 08/2009
9	Respiratory Tract Infections (Respiratory Tract Infection) 12/2007 - 04/2002
8	Ventilator-Associated Pneumonia 01/2020 - 04/2006
8	Communicable Diseases (Infectious Diseases) 01/2019 - 04/2009
5	Human Influenza (Influenza) 01/2019 - 12/2003
4	Lung Diseases (Lung Disease) 05/2021 - 01/2009
4	Sinusitis 05/2016 - 10/2002
4	Chronic Bronchitis 02/2005 - 08/2002
3	Hypertension (High Blood Pressure) 05/2021 - 04/2011
3	Intraabdominal Infections 01/2020 - 08/2009
3	Nausea 01/2019 - 04/2011
3	Pneumococcal Infections 05/2012 - 08/2003
2	Confusion (Bewilderment) 12/2021 - 03/2009
2	Chronic Obstructive Pulmonary Disease (COPD) 05/2021 - 01/2009
2	Diarrhea 04/2020 - 11/2002
2	Bacterial Infections (Bacterial Infection) 03/2020 - 01/2020
2	Urinary Tract Infections (Urinary Tract Infection) 01/2020 - 08/2009
2	Clostridium Infections 12/2019 - 04/2007
2	Vomiting 01/2019 - 03/2012
2	Sepsis (Septicemia) 05/2014 - 01/2012
2	Chronic Disease (Chronic Diseases) 05/2012 - 08/2002
2	Sleep Initiation and Maintenance Disorders (Insomnia) 04/2011 - 04/2011
2	Headache (Headaches) 04/2011 - 04/2011
2	Rhinosinusitis 06/2004 - 08/2002
1	Folliculitis (Sycosis) 01/2022
1	Coinfection 01/2022
1	Heart Failure 05/2021
1	Cardiac Arrhythmias (Arrythmia) 05/2021
1	Diabetes Mellitus 05/2021
1	Asthma (Bronchial Asthma) 05/2021
1	Cardiovascular Diseases (Cardiovascular Disease) 05/2021
1	Wound Infection (Wound Infections) 04/2020
1	Fatigue 04/2020
1	Gram-Negative Bacterial Infections 03/2020
1	Renal Insufficiency (Renal Failure) 03/2020
1	Acute Kidney Injury (Acute Renal Failure) 03/2020
1	Drug-Related Side Effects and Adverse Reactions 12/2019
1	Dental Enamel Hypoplasia 01/2019
1	Tooth Discoloration 01/2019
1	Body Weight (Weight, Body) 01/2018
1	Pharyngitis (Sore Throat) 05/2016
1	Suppurative Otitis Media 05/2016
1	Endocarditis 01/2012
1	Osteomyelitis 01/2012
1	Ulcer 01/2012
1	Diabetic Foot 01/2012
1	Soft Tissue Infections 01/2012

Drug/Important Bio-Agent (IBA)

26	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 04/2002
8	Pharmaceutical PreparationsIBA 01/2022 - 01/2002
8	Vancomycin FDA LinkGeneric 04/2020 - 01/2012
8	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 04/2016 - 11/2002
8	Ceftaroline FDA Link 04/2016 - 12/2010
7	lefamulinIBA 01/2022 - 11/2019
7	Moxifloxacin (Avelox)FDA Link 01/2022 - 10/2016
7	iclaprim (AR 100)IBA 04/2020 - 08/2017
7	MacrolidesIBA 08/2017 - 07/2002
6	PleuromutilinsIBA 01/2022 - 11/2019
5	Cephalosporins (Cephalosporin Antibiotics)IBA 09/2012 - 01/2002
5	FluoroquinolonesIBA 12/2004 - 01/2003
4	Linezolid (Zyvox)FDA Link 02/2021 - 01/2012
4	Amoxicillin (Wymox)FDA LinkGeneric 12/2007 - 10/2002
4	Clavulanic Acid (Potassium Clavulanate)FDA LinkGeneric 12/2007 - 10/2002
4	Levofloxacin (Levaquin)FDA Link 10/2006 - 10/2002
3	Carbapenems (Carbapenem Antibiotics)IBA 01/2020 - 01/2005
3	Antiviral Agents (Antivirals)IBA 01/2019 - 04/2009
3	Gemifloxacin (Factive)FDA Link 07/2007 - 11/2002
3	Anti-Infective Agents (Microbicides)IBA 02/2005 - 08/2002
3	Penicillins (Penicillin)FDA Link 02/2005 - 01/2002
3	beta-LactamsIBA 09/2004 - 01/2002
2	Urea (Carbamide)FDA LinkGeneric 12/2021 - 03/2009
2	EnzymesIBA 05/2021 - 11/2002
2	omadacyclineIBA 02/2021 - 01/2019
2	Imipenem FDA Link 03/2020 - 01/2020
2	Colistin (Coly-Mycin)FDA Link 03/2020 - 01/2020
2	Imipenem Drug Combination Cilastatin (Primaxin)FDA Link 03/2020 - 01/2005
2	relebactamIBA 03/2020 - 01/2020
2	ProdrugsIBA 04/2011 - 04/2011
2	VaccinesIBA 12/2010 - 12/2003
2	AntigensIBA 06/2010 - 09/2002
2	Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)FDA Link 12/2007 - 10/2002
1	NitrogenIBA 12/2021
1	Transaminases (Aminotransferases)IBA 01/2019
1	TetracyclinesIBA 01/2019
1	solithromycinIBA 10/2016
1	ProcalcitoninIBA 05/2014
1	Conjugate VaccinesIBA 12/2013
1	Methicillin (Metin)FDA Link 09/2012
1	Aztreonam FDA LinkGeneric 09/2012
1	Pneumococcal Vaccines (Pneumococcal Polysaccharide Vaccine)IBA 05/2012
1	ceftobiprole medocarilIBA 03/2012
1	ceftobiproleIBA 03/2012

Therapy/Procedure

33	Therapeutics 01/2022 - 08/2002
3	Chemoprevention 01/2019 - 04/2009
3	Critical Care (Surgical Intensive Care) 09/2016 - 06/2013
3	Length of Stay 02/2015 - 03/2010
3	Duration of Therapy 05/2014 - 01/2012
2	Ambulatory Care (Outpatient Care) 03/2010 - 01/2003